AIMOXIME

Cefuroxime injection

Cefuroxime Injection is a broad-spectrum antibiotic belonging to the second-generation cephalosporin class. It is used to treat various bacterial infections by inhibiting the synthesis of bacterial cell walls, ultimately causing the bacteria to die.

Cefuroxime

Class

Second-generation cephalosporin antibiotic

Action

Cefuroxime works by inhibiting the bacterial enzyme that synthesizes the cell wall, leading to bacterial cell death. It is effective against both gram-positive and gram-negative bacteria.

Stability

It is stable against beta-lactamase-producing bacteria, which makes it more effective against organisms that are resistant to some other antibiotics.

Indications

• Respiratory Tract Infections: Such as pneumonia, bronchitis, and sinusitis.
• Urinary Tract Infections: Including pyelonephritis and cystitis.
• Skin and Soft Tissue Infections: Caused by susceptible bacteria.
• Bone and Joint Infections: Such as osteomyelitis.
• Intra-abdominal Infections: Including peritonitis.
• Meningitis: In some cases, it can be used to treat bacterial meningitis.
• Gonorrhea: Cefuroxime is effective in treating certain sexually transmitted infections like gonorrhea.

Dosage and Administration

• Adults:

  The typical dose for adults is 750 mg to 1.5 g every 8 to 12 hours, depending on the severity of the infection.

• Children:

  Dosing for children is based on weight, generally between 30-100 mg per kg body weight per day, divided into two or three doses.

• Administration:

  Cefuroxime injection is usually given intravenously (IV) or intramuscularly (IM) by healthcare providers. IV administration is typically preferred for more severe infections.

• Duration:

  The duration of treatment depends on the type of infection and its severity but typically lasts from 5 to 14 days.

Side Effects

Common side effects include:

• Gastrointestinal: Nausea, vomiting, diarrhea, or abdominal pain.
• Allergic reactions: Rash, itching, or anaphylaxis (severe allergic reaction).
• Injection site reactions: Pain, redness, or swelling at the site of injection.
• Hematologic: Temporary changes in blood cell counts, such as low white blood cell or platelet counts.
• Liver Enzyme Elevations: Increased liver enzymes may occur during treatment.

Precautions:

• Caution is advised in patients with a history of allergy to cephalosporins or penicillins.
• Adjustments may be needed for patients with renal (kidney) impairment.
• As with all antibiotics, prolonged use can lead to a secondary infection, such as yeast infections, or resistance..